Publications
2013
101. Guo H, Isserlin R, Chen X, Wang W, Phanse S, Zandstra PW, Paddison PJ, Emili A. (2013) Integrative network analysis of signaling in human CD34+ hematopoetic progenitor cells by global phosphoproteomic profiling using TiO2 enrichment combined with 2D LC-MS/MS and pathway mapping.
2012
100. Csazar E, Cohen S, Zandstra PW. (2012) Blood stem cell products: Toward sustainable benchmarks for clinical translation.
99. Qiao W, Quon G, Csazar E, Yu M, Morris Q, Zandstra PW. (2012) PERT: A Method for Expression Deconvolution of Human Blood Samples from Varied Microenvironmental and Developmental Conditions.
98. Onishi K, Tonge PD, Nagy A, Zandstra PW. (2012) Microenvironment-mediated reversion of epiblast stem cells by reactivation of repressed JAK-STAT signaling.
97. Baptista RP, Fluri DA, Zandstra PW. (2012) High density continuous production of murine pluripotent cells in an acoustic perfused bioreactor at different oxygen concentrations.
96. Reynolds JG, Geretti E, Hendriks BS, Lee H, Leonard SC, Klinz SG, Noble CO, Lücker PB, Zandstra PW, Drummond DC, Olivier KJ Jr, Nielsen UB, Niyikiza C, Agresta SV, Wickham TJ. (2012) HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity.
95. Fluri DA, Tonge PD, Song H, Baptista RP, Shakiba N, Shukla S, Clarke G, Nagy A, Zandstra PW. (2012) Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures.
94. Woodford C, Zandstra PW. (2012) Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation.
93. Moledina F, Clarke G, Oskooei A, Onishi K, Guenther A, Zandstra PW. (2012) Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells.
92. Csaszar E, Kirouac DC, Yu M, Wang W, Qiao W, Cooke MP, Boitano AE, Ito C, Zandstra PW. (2012) Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.
2011
91. Ungrin MD, Clarke G, Yin T, Niebrugge S, Nostro MC, Sarangi F, Wood G, Keller G, Zandstra PW. (2011) Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics.
90. Ishida M, El-Mounayri O, Kattman S, Zandstra P, Sakamoto H, Ogawa M, Keller G, Husain M. (2011) Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells.
89. Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. (2011) A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues.
88. Purpura KA, Bratt-Leal AM, Hammersmith KA, McDevitt TC, Zandstra PW. (2011) Systematic engineering of 3D pluripotent stem cell niches to guide blood development.
87. Parrag IC, Zandstra PW, Woodhouse KA. (2011) Fiber alignment and coculture with fibroblasts improves the differentiated phenotype of murine embryonic stem cell-derived cardiomyocytes for cardiac tissue engineering.
86. Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ. (2011) An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.
85. Matsuura K, Masuda S, Haraguchi Y, Yasuda N, Shimizu T, Hagiwara N, Zandstra PW, Okano T. (2011) Creation of mouse embryonic stem cell-derived cardiac cell sheets.
84. Song H, Zandstra PW, Radisic M. (2011) Engineered heart tissue model of diabetic myocardium.
83. Bauwens CL, Song H, Thavandiran N, Ungrin M, Massé S, Nanthakumar K, Seguin C, Zandstra PW. (2011) Geometric control of cardiomyogenic induction in human pluripotent stem cells.
82. Tumarkin E, Tzadu L, Csaszar E, Seo M, Zhang H, Lee A, Peerani R, Purpura K, Zandstra PW, Kumacheva E. (2011) High-throughput combinatorial cell co-culture using microfluidics.
2010
81. Dengler J, Song H, Thavandiran N, Massé S, Wood GA, Nanthakumar K, Zandstra PW, Radisic M. (2010) Engineered heart tissue enables study of residual undifferentiated embryonic stem cell activity in a cardiac environment.
80. Kumachev A, Greener J, Tumarkin E, Eiser E, Zandstra PW, Kumacheva E. (2010) High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation.
79. Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW. (2010) Dynamic interaction networks in a hierarchically organized tissue.
78. Bratt-Leal AM, Carpenedo RL, Ungrin MD, Zandstra PW, McDevitt TC. (2010) Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation.
77. Rahman N, Purpura KA, Wylie RG, Zandstra PW, Shoichet MS. (2010) The use of vascular endothelial growth factor functionalized agarose to guide pluripotent stem cell aggregates toward blood progenitor cells.
76. Peerani R, Zandstra PW. (2010) Enabling stem cell therapies through synthetic stem cell-niche engineering.
75. Pompe T, Salchert K, Alberti K, Zandstra P, Werner C. (2010) Immobilization of growth factors on solid supports for the modulation of stem cell fate.
74. Hewel JA, Liu J, Onishi K, Fong V, Chandran S, Olsen JB, Pogoutse O, Schutkowski M, Wenschuh H, Winkler DF, Eckler L, Zandstra PW, Emili A. (2010) Synthetic peptide arrays for pathway-level protein monitoring by LC-MS/MS.
73. Song H, Yoon C, Kattman SJ, Dengler J, Massé S, Thavaratnam T, Gewarges M, Nanthakumar K, Rubart M, Keller GM, Radisic M, Zandstra PW. (2010) Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue.
2009
72. International Stem Cell Banking Initiative. (2009) Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes.
71. Lee LH, Peerani R, Ungrin M, Joshi C, Kumacheva E, Zandstra P. (2009) Micropatterning of human embryonic stem cells dissects the mesoderm and endoderm lineages.
70. Ito CY, Kirouac DC, Madlambayan GJ, Yu M, Rogers I, Zandstra PW. (2009) The AC133+CD38-, but not the rhodamine-low, phenotype tracks LTC-IC and SRC function in human cord blood ex vivo expansion cultures.
69. Song H, Yoon C, Kattman SJ, Dengler J, Massé S, Thavaratnam T, Gewarges M, Nanthakumar K, Rubart M, Keller GM, Radisic M, Zandstra PW. (2009) Regenerative Medicine Special Feature: Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue.
68. Peerani R, Onishi K, Mahdavi A, Kumacheva E, Zandstra PW. (2009) Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens.
67. Kirouac DC, Madlambayan GJ, Yu M, Sykes EA, Ito C, Zandstra PW. (2009) Cell-cell interaction networks regulate blood stem and progenitor cell fate.
66. Discher DE, Mooney DJ, Zandstra PW. (2009) Growth factors, matrices, and forces combine and control stem cells.
65. Csaszar E, Gavigan G, Ungrin M, Thérien C, Dubé P, Féthière J, Sauvageau G, Roy DC, Zandstra PW. (2009) An automated system for delivery of an unstable transcription factor to hematopoietic stem cell cultures.
64. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. (2009) Alternative induced pluripotent stem cell characterization criteria for in vitro applications.
63. Zandstra PW. (2009) Pairing cells to enhance fusion.
62. Peerani R, Bauwens C, Kumacheva E, Zandstra PW. (2009) Patterning mouse and human embryonic stem cells using micro-contact printing.
61. Niebruegge S, Bauwens CL, Peerani R, Thavandiran N, Masse S, Sevaptisidis E, Nanthakumar K, Woodhouse K, Husain M, Kumacheva E, Zandstra PW. (2009) Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor.
2008
60. Kirouac DC, Zandstra PW. (2008) The systematic production of cells for cell therapies.
59. Purpura KA, George SH, Dang SM, Choi K, Nagy A, Zandstra PW. (2008) Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner.
58. Coles-Takabe BL, Brain I, Purpura KA, Karpowicz P, Zandstra PW, Morshead CM, van der Kooy D. (2008) Don't look: growing clonal versus nonclonal neural stem cell colonies.
57. Tanaka TS, Davey RE, Lan Q, Zandstra PW, Stanford WL. (2008) Development of a gene-trap vector with a highly sensitive fluorescent protein reporter system for expression profiling.
56. Bauwens CL, Peerani R, Niebruegge S, Woodhouse KA, Kumacheva E, Husain M, Zandstra PW. (2008) Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories.
55. Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL. (2008) TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
54. Alberti K, Davey RE, Onishi K, George S, Salchert K, Seib FP, Bornhäuser M, Pompe T, Nagy A, Werner C, Zandstra PW. (2008) Functional immobilization of signaling proteins enables control of stem cell fate.
53. Purpura KA, Morin J, Zandstra PW. (2008) Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media.
52. Fromstein JD, Zandstra PW, Alperin C, Rockwood D, Rabolt JF, Woodhouse KA. (2008) Seeding bioreactor-produced embryonic stem cell-derived cardiomyocytes on different porous, degradable, polyurethane scaffolds reveals the effect of scaffold architecture on cell morphology.
51. Ungrin MD, Joshi C, Nica A, Bauwens C, Zandstra PW. (2008) Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates.
50. Wang W, Horner DN, Chen WL, Zandstra PW, Audet J. (2008) Synergy between erythropoietin and stem cell factor during erythropoiesis can be quantitatively described without co-signaling effects.
2007
49. Ungrin M, O'Connor M, Eaves C, Zandstra PW. (2007) Phenotypic analysis of human embryonic stem cells.
48. Walker E, Ohishi M, Davey RE, Zhang W, Cassar PA, Tanaka TS, Der SD, Morris Q, Hughes TR, Zandstra PW, Stanford WL. (2007) Prediction and testing of novel transcriptional networks regulating embryonic stem cell self-renewal and commitment.
47. Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, Nagy A, Kumacheva E, Zandstra PW. (2007) Niche-mediated control of human embryonic stem cell self-renewal and differentiation.
46. Mahdavi A, Davey RE, Bhola P, Yin T, Zandstra PW. (2007) Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control.
45. Baksh D, Zandstra PW, Davies JE. (2007) A non-contact suspension culture approach to the culture of osteogenic cells derived from a CD49elow subpopulation of human bone marrow-derived cells.
44. *Alperin C, Zandstra PW, Woodhouse KA. (2007) Engineering cardiac healing using embryonic stem cell-derived cardiac cell seeded constructs.
43. Davey RE, Onishi K, Mahdavi A, Zandstra PW. (2007) LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop.
2006
42. Madlambayan GJ, Rogers I, Purpura KA, Ito C, Yu M, Kirouac D, Casper RF, Zandstra PW. (2006) Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess.
41. Kirouac DC, Zandstra PW. (2006) Understanding cellular networks to improve hematopoietic stem cell expansion cultures.
40. Davey RE, Zandstra PW. (2006) Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche.
39. Hasman A, Moorman P, de Vries-Robbé PF, Bindels R, Zandstra P, van Ast W, van der Lei J. (2006) EGOOZ: specifying the components of electronic patient record-related education.
2005
28. Madlambayan GJ, Rogers I, Kirouac DC, Yamanaka N, Mazurier F, Doedens M, Casper RF, Dick JE, Zandstra PW. (2005) Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion.
37. Rosu-Myles M, Stewart E, Trowbridge J, Ito CY, Zandstra P, Bhatia M. (2005) A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis.
36. Fok EY, Zandstra PW. (2005) Shear-controlled single-step mouse embryonic stem cell expansion and embryoid body-based differentiation.
35. Baksh D, Davies JE, Zandstra PW. (2005) Soluble factor cross-talk between human bone marrow-derived hematopoietic and mesenchymal cells enhances in vitro CFU-F and CFU-O growth and reveals heterogeneity in the mesenchymal progenitor cell compartment.
34. Viswanathan S, Davey RE, Cheng D, Raghu RC, Lauffenburger DA, Zandstra PW. (2005) Clonal evolution of stem and differentiated cells can be predicted by integrating cell-intrinsic and -extrinsic parameters.
33. Bauwens C, Yin T, Dang S, Peerani R, Zandstra PW. (2005) Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output.
32. *Dang SM, Zandstra PW. (2005) Scalable production of embryonic stem cell-derived cells.
31. Rao BM, Zandstra PW. (2005) Culture development for human embryonic stem cell propagation: molecular aspects and challenges.
30. Alperin C, Zandstra PW, Woodhouse KA. (2005) Polyurethane films seeded with embryonic stem cell-derived cardiomyocytes for use in cardiac tissue engineering applications.
2004
29. Chang KH, Zandstra PW. (2004) Quantitative screening of embryonic stem cell differentiation: endoderm formation as a model.
28. Zandstra PW. (2004) The opportunity of stem cell bioengineering.
27. Davey RE, Zandstra PW. (2004) Signal processing underlying extrinsic control of stem cell fate.
26. Dang SM, Gerecht-Nir S, Chen J, Itskovitz-Eldor J, Zandstra PW. (2004) Controlled, scalable embryonic stem cell differentiation culture.
25. Prudhomme W, Daley GQ, Zandstra P, Lauffenburger DA. (2004) Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling.
24. Purpura KA, Aubin JE, Zandstra PW. (2004) Sustained in vitro expansion of bone progenitors is cell density dependent.
2003
23. Viswanathan S, Zandstra PW. (2003) Towards predictive models of stem cell fate.
22. Viswanathan S, Benatar T, Mileikovsky M, Lauffenburger DA, Nagy A, Zandstra PW. (2003) Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis.
21. Purpura KA, Zandstra PW, Aubin JE. (2003) Fluorescence activated cell sorting reveals heterogeneous and cell non-autonomous osteoprogenitor differentiation in fetal rat calvaria cell populations.
20. Baksh D, Davies JE, Zandstra PW. (2003) Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion.
19. Purpura KA, Aubin JE, Zandstra PW. (2003) Two-color image analysis discriminates between mineralized and unmineralized bone nodules in vitro.
18. Zandstra PW, Bauwens C, Yin T, Liu Q, Schiller H, Zweigerdt R, Pasumarthi KB, Field LJ. (2003) Scalable production of embryonic stem cell-derived cardiomyocytes.
2002
17. Dang SM, Kyba M, Perlingeiro R, Daley GQ, Zandstra PW. (2002) Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems.
16. Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW. (2002) Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6.
15. Madras N, Gibbs AL, Zhou Y, Zandstra PW, Aubin JE. (2002) Stem Cells. Modeling stem cell development by retrospective analysis of gene expression profiles in single progenitor-derived colonies.
2001
14. Madlambayan GJ, Rogers I, Casper RF, Zandstra PW. (2001) Controlling culture dynamics for the expansion of hematopoietic stem cells.
13. Zandstra PW, Nagy A. (2001) Stem cell bioengineering.
2000
12. Zandstra PW, Lauffenburger DA, Eaves CJ. (2000) A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis.
11. Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA. (2000) Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation.
1999
10. Eaves C, Miller C, Conneally E, Audet J, Oostendorp R, Cashman J, Zandstra P, Rose-John S, Piret J, Eaves A. (1999) Introduction to stem cell biology in vitro. Threshold to the future.
9. Zandstra PW, Jervis E, Haynes CA, Kilburn DG, Eaves CJ, Piret JM. (1999) Concentration-dependent internalization of a cytokine/cytokine receptor complex in human hematopoietic cells.
1998
8. Eaves C, Zandstra P, Conneally E, Miller C, Cashman J, Petzer A, Piret J. (1998) Changes in the cytokine regulation of stem cell self-renewal during ontogeny.
7. Zandstra PW, Conneally E, Piret JM, Eaves CJ. (1998) Ontogeny-associated changes in the cytokine responses of primitive human haemopoietic cells.
6. Audet J, Zandstra PW, Eaves CJ, Piret JM. (1998) Advances in hematopoietic stem cell culture.
1997
5. Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ. (1997) Cytokine manipulation of primitive human hematopoietic cell self-renewal.
4. Zandstra PW, Petzer AL, Eaves CJ, Piret JM. (1997) Cellular determinants affecting the rate of cytokine in cultures of human hematopoietic cells.
3. Eaves C, Miller C, Cashman J, Conneally E, Petzer A, Zandstra P, Eaves A. (1997) Hematopoietic stem cells: inferences from in vivo assays.
1996
2. Petzer AL, Zandstra PW, Piret JM, Eaves CJ. (1996) Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.
1994
1. Zandstra PW, Eaves CJ, Piret JM. (1994) Expansion of hematopoietic progenitor cell populations in stirred suspension bioreactors of normal human bone marrow cells.
Source: http://www.ncbi.nlm.nih.gov/sites/entrez
